When something disturbs

When something disturbs the vestibular apparatus, such as movements of the head when travelling by boat or car, nerve signals are sent from the vestibular apparatus to the vomiting centre. This can cause the symptoms of motion sickness, such as nausea, dizziness or spinning sensations (vertigo) and vomiting. Promethazine can be used to prevent motion sickness, because by blocking the histamine receptors in the vomiting centre, it prevents disturbances in the middle ear from activating the vomiting centre.Promethazine is known as a sedating antihistamine because it enters the brain in significant quantities and causes drowsiness.

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